Dlx1/2 mice have abnormal enteric nervous system function

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

al., 1996), PSP was found to have no survival-promoting effects on these populations (Milbrandt et al., 1998). Hideki Enomoto,* Toshiyuki Araki,* Alana Jackman,† Robert O. Heuckeroth,§ William D. Snider,† Eugene M. Johnson, Jr.,†‡ and Jeffrey Milbrandt*‖ Although GDNF is a potentneurotrophic factor in vitro, *Departments of Pathology and Internal Medicine the phenotype of mice deficient in GDNF...

متن کامل

The enteric nervous system.

T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...

متن کامل

SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice.

The 2007 Consensus Statement for Standard of Care in Spinal Muscular Atrophy (SMA) notes that patients suffer from gastroesophageal reflux, constipation and delayed gastric emptying. We used two mouse models of SMA to determine whether functional GI complications are a direct consequence of or are secondary to survival motor neuron (Smn) deficiency. Our results show that despite normal activity...

متن کامل

The human enteric nervous system.

Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...

متن کامل

Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice.

alpha(2A)-Adrenergic receptors (ARs) in the midbrain regulate sympathetic nervous system activity, and both alpha(2A)-ARs and alpha(2C)-ARs regulate catecholamine release from sympathetic nerve terminals in cardiac tissue. Disruption of both alpha(2A)- and alpha(2C)-ARs in mice leads to chronically elevated sympathetic tone and decreased cardiac function by 4 mo of age. These knockout mice have...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: JCI Insight

سال: 2020

ISSN: 2379-3708

DOI: 10.1172/jci.insight.131494